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Abnova
CDK6 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
CDK6 Antibody (H00001021-D01P) in WB
Western Blot analysis of CDK6 expression in transfected 293T cell line (H00001021-T02) by CDK6 MaxPab polyclonal antibody.
Lane 1: CDK6 transfected lysate(36.90 KDa).
Lane 2: Non-transfected lysate.
Lane 1: CDK6 transfected lysate(36.90 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00001021-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDK6 (NP_001250.1, 1 a.a. approximately 326 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF QDLERCKENL DSHLPPSQNT SELNTA
Target Information
CDK6 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene results in microcephaly 12, primary, autosomal recessive (MCPH12).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell division protein kinase 6; Cyclin-dependent kinase 6; MGC59692; Serine/threonine-protein kinase PLSTIRE
Gene Aliases: CDK6; CDKN6; MCPH12; PLSTIRE
UniProt ID: (Human) Q00534
Entrez Gene ID: (Human) 1021
G1/S transition of mitotic cell cycle
positive regulation of cell-matrix adhesion
type B pancreatic cell development
protein phosphorylation
cell cycle arrest
Notch signaling pathway
negative regulation of cell proliferation
response to virus
regulation of gene expression
positive regulation of gene expression
astrocyte development
dentate gyrus development
lateral ventricle development
T cell differentiation in thymus
gliogenesis
cell dedifferentiation
negative regulation of cell differentiation
negative regulation of myeloid cell differentiation
regulation of erythrocyte differentiation
negative regulation of monocyte differentiation
negative regulation of osteoblast differentiation
negative regulation of cell cycle
positive regulation of fibroblast proliferation
generation of neurons
negative regulation of epithelial cell proliferation
cell division
hematopoietic stem cell differentiation
cellular response to phorbol 13-acetate 12-myristate
regulation of cell motility
negative regulation of cellular senescence
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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