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Invitrogen
CDK6 Polyclonal Antibody
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Product Details
PA5-102420
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDK6(Accession Q00534), corresponding to amino acid residues M1-Q48.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CDK6.
Target Information
CDK6 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene results in microcephaly 12, primary, autosomal recessive (MCPH12).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell division protein kinase 6; CR2 protein kinase; CRK2; Cyclin-dependent kinase 6; MGC59692; Serine/threonine-protein kinase PLSTIRE
Gene Aliases: 5830411I20; AI504062; CDK6; CDKN6; Crk2; MCPH12; PLSTIRE
UniProt ID: (Human) Q00534, (Mouse) Q64261
Entrez Gene ID: (Human) 1021, (Rat) 114483, (Mouse) 12571
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
cyclin binding
kinase activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
positive regulation of cell-matrix adhesion
type B pancreatic cell development
protein phosphorylation
cell cycle arrest
Notch signaling pathway
negative regulation of cell proliferation
response to virus
regulation of gene expression
positive regulation of gene expression
astrocyte development
dentate gyrus development
lateral ventricle development
T cell differentiation in thymus
gliogenesis
cell dedifferentiation
negative regulation of cell differentiation
negative regulation of myeloid cell differentiation
regulation of erythrocyte differentiation
negative regulation of monocyte differentiation
negative regulation of osteoblast differentiation
negative regulation of cell cycle
positive regulation of fibroblast proliferation
generation of neurons
negative regulation of epithelial cell proliferation
cell division
hematopoietic stem cell differentiation
cellular response to phorbol 13-acetate 12-myristate
regulation of cell motility
negative regulation of cellular senescence
hematopoietic progenitor cell differentiation
phosphorylation
hemopoiesis
cell cycle
cell differentiation
regulation of cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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