Positive Control: IMR32, Jurkat, Raji, NCI-H929
Predicted Reactivity: Mouse (93%), Rat (93%), Chicken (85%), Rhesus Monkey (100%), Bovine (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
CDK6, a cyclin-dependent kinase 6 (p40cdk6 also known as PLSTIRE) belongs to a family of proteins designated as cdks. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene results in microcephaly 12, primary, autosomal recessive (MCPH12).
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDK6; Cell division protein kinase 6; Cyclin-dependent kinase 6; MGC59692; PLSTIRE; Serine/threonine-protein kinase PLSTIRE
Gene Aliases: CDK6; CDKN6; MCPH12; PLSTIRE
UniProt ID: (Human) Q00534
Entrez Gene ID: (Human) 1021