Immunogen sequence: NLIPRHQELF NKNPVFAGVR LPEIKEREPL ERRYPKLSEV VIDLAKKCLH IDPDKRPFCA ELLHHDFFQM DGFAERFSQE LQLKVQKDAR NVSLSKKSQN RKKEKEKDDS LVEERKTLVV QDTNADPK
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDC2-related kinase; Cyclin-dependent kinase-like 2; cyclin-dependent kinase-like 2 (CDC2-related kinase); p56 KKIAMRE protein kinase; Protein kinase p56 KKIAMRE; serine/threonine protein kinase KKIAMRE; Serine/threonine-protein kinase KKIAMRE; testicular tissue protein Li 35
Gene Aliases: CDKL2; KKIAMRE; P56
UniProt ID: (Human) Q92772
Entrez Gene ID: (Human) 8999
Molecular Function: non-receptor serine/threonine protein kinase