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Invitrogen
CDKN2B (Isoform 2) Polyclonal Antibody
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FIGURE: 1 / 1
CDKN2B (Isoform 2) Antibody (PA5-142832) in WB
Western Blot analysis of CDKN2B (Isoform 2) in Human Gastrointestinal cancer lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide using CDKN2B (Isoform 2) Polyclonal Antibody (Product # PA5-142832) at 1 µg/mL incubated for 1 hour. Detected by chemiluminescence.
Product Details
PA5-142832
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-RQGARERGARP.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognize isoform 2 (NP_511042.1) only.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK inhibitory protein; CDK4B inhibitor; CDKN2B; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; MTS-2; Multiple tumor suppressor 2; p10; p14-INK4b; p14_CDK inhibitor; p14_INK4B; p15; p15 CDK inhibitor; p15-INK4b; p15_INK4B; p15INK4B
Gene Aliases: CDK4I; CDKN2B; INK4B; MTS2; P15; p15INK4b; TP15
UniProt ID: (Human) P42772
Entrez Gene ID: (Human) 1030
transforming growth factor beta receptor signaling pathway
negative regulation of cell proliferation
megakaryocyte differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
cellular response to nutrient
spleen development
negative regulation of epithelial cell proliferation
regulation of G0 to G1 transition
cellular response to cell-matrix adhesion
cellular senescence
regulation of G1/S transition of mitotic cell cycle
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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