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The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Cdk-associated protein phosphatase; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; CDK2-associated dual-specificity phosphatase {ECO:0000250|UniProtKB:Q16667}; cdkn3; cdkn3 {ECO:0000312|EMBL:AAI67026.1, ECO:0000312|RGD:1307781}; cyclin-dependent kinase inhibitor; Cyclin-dependent kinase inhibitor 3; cyclin-dependent kinase inhibitor 3 {ECO:0000250|UniProtKB:Q16667}; cyclin-dependent kinase interacting protein 2; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; kinase associated phosphatase; Kinase-associated phosphatase; kinase-associated phosphatase {ECO:0000250|UniProtKB:Q16667}
Gene Aliases: 2410006H10Rik; CDI1; CDKN3; CIP2; KAP; KAP1
UniProt ID: (Human) Q16667, (Mouse) Q810P3, (Rat) B2RZ50
Entrez Gene ID: (Human) 1033, (Mouse) 72391, (Rat) 289993
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