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Invitrogen
CDKN3 Polyclonal Antibody
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FIGURE: 1 / 7
CDKN3 Antibody (PA5-106908) in ICC/IF
Immunocytochemistry analysis of CDKN3 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CDKN3 polyclonal antibody (Product # PA5-106908) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-106908
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDKN3(Accession Q16667), corresponding to amino acid residues L32-G82.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CDKN3.
Target Information
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cdk-associated protein phosphatase; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; CDK2-associated dual-specificity phosphatase {ECO:0000250|UniProtKB:Q16667}; cdkn3; cdkn3 {ECO:0000312|EMBL:AAI67026.1, ECO:0000312|RGD:1307781}; cyclin-dependent kinase inhibitor; Cyclin-dependent kinase inhibitor 3; cyclin-dependent kinase inhibitor 3 {ECO:0000250|UniProtKB:Q16667}; cyclin-dependent kinase interacting protein 2; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; kinase associated phosphatase; Kinase-associated phosphatase; kinase-associated phosphatase {ECO:0000250|UniProtKB:Q16667}
Gene Aliases: 2410006H10Rik; CDI1; CDKN3; CIP2; KAP; KAP1
UniProt ID: (Human) Q16667, (Mouse) Q810P3
Entrez Gene ID: (Human) 1033, (Mouse) 72391, (Rat) 289993
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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