Proteintech

CDO1 Polyclonal Antibody

CDO1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CDO1 Antibody (12589-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 12589-1-AP (CDO1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CDO1 Antibody in Immunoprecipitation (IP)

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Product Details

12589-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDO1 Fusion Protein Ag3294 (1-200 aa encoded by BC024241)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEQTEVLKP RTLADLIRIL HQLFAGDEVN VEEVQAIMEA YESDPTEWAM YAKFDQYRYT RNLVDQGNGK FNLMILCWGE GHGSSIHDHT NSHCFLKMLQ GNLKETLFAW PDKKSNEMVK KSERVLRENQ CAYINDSVGL HRVENISHTE PAVSLHLYSP PFDTCHAFDQ RTGHKNKVTM TFHSKFGIRT PNATSGSLEN N (1-200 aa encoded by BC024241)

Target Information

CDO1 (cysteine dioxygenase, type I) belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis. CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine. CDO1 exists as a monomer and is expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart. CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.

Cellular and molecular neurobiology

Zhu Y,Wang R,Fan Z,Luo D,Cai G,Li X,Han J,Zhuo L,Zhang L,Zhang H,Li Y,Wu S

Wed Mar 01 00:00:00 UTC 2023

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors.

Cancer research

Yoon SJ,Combs JA,Falzone A,Prieto-Farigua N,Caldwell S,Ackerman HD,Flores ER,DeNicola GM

Tue May 02 00:00:00 UTC 2023

Testosterone enhances taurine synthesis by upregulating androgen receptor and cysteine sulfinic acid decarboxylase expressions in male mouse liver.

American journal of physiology. Gastrointestinal and liver physiology

Zhang D,Fan J,Liu H,Qiu G,Cui S

Sat Apr 01 00:00:00 UTC 2023

Integrated application of transcriptome and metabolomics reveals potential therapeutic targets for the polarization of atherosclerotic macrophages.

Biochimica et biophysica acta. Molecular basis of disease

Shen L,Li H,Chen W,Su Y,Yu J,Chen M,Shu G,Qiao E,Guo X,Xu M,Xia S,Zhao Z,Lu C,Ji J

Thu Dec 01 00:00:00 UTC 2022

Integration of metabolomics and transcriptomics to reveal anti-chronic myocardial ischemia mechanism of Gualou Xiebai decoction.

Journal of ethnopharmacology

Zhang F,Duan B,Zhou Z,Han L,Huang P,Ye Y,Wang Q,Huang F,Li J

Fri Oct 28 00:00:00 UTC 2022

Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice.

Nature metabolism

Guo YY,Li BY,Xiao G,Liu Y,Guo L,Tang QQ

Sat Oct 01 00:00:00 UTC 2022

Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.

Cell death discovery

Ma G,Zhao Z,Qu Y,Cai F,Liu S,Liang H,Zhang R,Deng J

Fri Dec 16 00:00:00 UTC 2022

Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.

Cell death discovery

Ma G,Zhao Z,Qu Y,Cai F,Liu S,Liang H,Zhang R,Deng J

Fri Dec 16 00:00:00 UTC 2022

Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer.

International journal of biological sciences

Luo W,Dai W,Li Q,Mo S,Han L,Xiao X,Gu R,Xiang W,Ye L,Wang R,Xu Y,Cai S,Cai G

Fri Apr 15 00:00:00 UTC 2022

ADO/hypotaurine: a novel metabolic pathway contributing to glioblastoma development.

Cell death discovery

Shen D,Tian L,Yang F,Li J,Li X,Yao Y,Lam EW,Gao P,Jin B,Wang R

Fri Jan 22 00:00:00 UTC 2021

Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN).

Annals of surgical oncology

Fujiyama Y,Kumamoto Y,Nishizawa N,Nakamoto S,Harada H,Yokota K,Tanaka Y,Igarashi K,Oiki H,Okuwaki K,Iwai T,Kajita S,Takahashi H,Tajima H,Kaizu T,Sasaki J,Watanabe M,Yamashita K

Thu Oct 01 00:00:00 UTC 2020

Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer.

PloS one

Kojima K,Nakamura T,Ooizumi Y,Igarashi K,Tanaka T,Yokoi K,Ishii S,Nishizawa N,Katoh H,Kosaka Y,Sato T,Watanabe M,Yamashita K

Wed Oct 23 00:00:00 UTC 2019

Cancer-specific promoter DNA methylation of Cysteine dioxygenase type 1 (CDO1) gene as an important prognostic biomarker of gastric cancer.

PloS one

Harada H,Hosoda K,Moriya H,Mieno H,Ema A,Ushiku H,Washio M,Nishizawa N,Ishii S,Yokota K,Tanaka Y,Kaida T,Soeno T,Kosaka Y,Watanabe M,Yamashita K

Thu Jan 02 00:00:00 UTC 2020

Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.

PloS one

Kojima K,Nakamura T,Ohbu M,Katoh H,Ooizumi Y,Igarashi K,Ishii S,Tanaka T,Yokoi K,Nishizawa N,Yokota K,Kosaka Y,Sato T,Watanabe M,Yamashita K

Mon Jul 30 00:00:00 UTC 2018

Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.

PloS one

Kojima K,Nakamura T,Ohbu M,Katoh H,Ooizumi Y,Igarashi K,Ishii S,Tanaka T,Yokoi K,Nishizawa N,Yokota K,Kosaka Y,Sato T,Watanabe M,Yamashita K

Mon Jul 30 00:00:00 UTC 2018

Hepatic metabolite profiles in mice with a suboptimal selenium status.

The Journal of nutritional biochemistry

Geillinger KE,Rathmann D,Köhrle J,Fiamoncini J,Daniel H,Kipp AP

Mon Sep 01 00:00:00 UTC 2014

Hepatic metabolite profiles in mice with a suboptimal selenium status.

The Journal of nutritional biochemistry

Geillinger KE,Rathmann D,Köhrle J,Fiamoncini J,Daniel H,Kipp AP

Mon Sep 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: CDO; CDO-I; CDOI; cysteine dioxygenase 1, cytosolic; Cysteine dioxygenase type 1; Cysteine dioxygenase type I; cysteine dioxygenase, type I; cytosolic cysteine dioxygenase 1

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Gene Aliases: 1300002L19Rik; Cdo; CDO-I; CDO1; D18Ucla3

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UniProt ID: (Human) Q16878, (Rat) P21816, (Mouse) P60334

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Entrez Gene ID: (Human) 1036, (Pig) 100312964, (Rat) 81718, (Mouse) 12583

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Function(s)

ferrous iron binding cysteine dioxygenase activity iron ion binding oxidoreductase activity metal ion binding dioxygenase activity oxidoreductase oxygenase metabolite interconversion enzyme

Process(es)

sulfur amino acid biosynthetic process cysteine metabolic process inflammatory response lactation L-cysteine catabolic process L-cysteine catabolic process to pyruvate, using cysteine dioxygenase response to glucagon taurine biosynthetic process response to amino acid response to ethanol response to glucocorticoid response to cAMP oxidation-reduction process response to organonitrogen compound L-cysteine metabolic process L-cysteine catabolic process to taurine taurine metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDO1 Polyclonal Antibody

CDO1 Antibody (12589-1-AP) in IHC (P)

Product Details

12589-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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