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Immunogen sequence: GVEKLVPDSL YVPFKEPSQS LLEEMFLTVP ESHRKPLKRS SSETILSSLA GSDIVKGHEE TCIRRAKAVK QRGISLLHEV DTQYSALKVK YEELLKKCQE EQDSLSHKAV QTSRAAAKDL TGV
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Using anti-Yo antibodies, three genes have been cloned (CDR 1-3). CDR2 suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by an unknown mechanism. The neuron specific expression of CDR2 is regulated by a post-transcriptional mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cerebellar degeneration-related protein 2; cerebellar degeneration-related protein 2, 62kDa; Major Yo paraneoplastic antigen; Paraneoplastic cerebellar degeneration-associated antigen; Yo paraneoplastic antigen
Gene Aliases: CDR2; CDR62; PCD17; Yo
UniProt ID: (Human) Q01850
Entrez Gene ID: (Human) 1039
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