Proteintech

CDT1 Polyclonal Antibody

FIGURE: 1 / 3

CDT1 Antibody (14382-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 14382-1-AP) (CDT1 antibody) at dilution of 1:4,000 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

14382-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

Assay-dependent

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDT1 Fusion Protein Ag5810 (195-546 aa encoded by BC000137)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EMFRSMDTI VGMLHNRSET PTFAKVQRGV QDMMRRRFEE RNVGQIKTVY PASYRFRQER SVPTFKDGTR RSDYQLTIEP LLEQEADGAA PQLTASRLLQ RRQIFSQKLV EHVKEHHKAF LASLSPAMVV PEDQLTRWHP RFNVDEVPDI EPAALPQPPA TEKLTTAQEV LARARNLISP RMEKALSQLA LRSAAPSSPG SPRPALPATP PATPPAASPS ALKGVSQDLL ERIRAKEAQK QLAQMTRCPE QEQRLQRLER LPELARVLRS VFVSERKPAL SMEVACARMV GSCCTIMSPG EMEKHLLLLS ELLPDWLSLH RIRTDTYVKL DKAADLAHIT ARLAHQTRAE EGL (195-546 aa encoded by BC000137)

Target Information

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma.

Scientific reports

Moriyama M,Kanda T,Midorikawa Y,Matsumura H,Masuzaki R,Nakamura H,Ogawa M,Matsuoka S,Shibata T,Yamazaki M,Kuroda K,Nakayama H,Higaki T,Kanemaru K,Miki T,Sugitani M,Takayama T

Mon Nov 28 00:00:00 UTC 2022

The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma.

Scientific reports

Moriyama M,Kanda T,Midorikawa Y,Matsumura H,Masuzaki R,Nakamura H,Ogawa M,Matsuoka S,Shibata T,Yamazaki M,Kuroda K,Nakayama H,Higaki T,Kanemaru K,Miki T,Sugitani M,Takayama T

Mon Nov 28 00:00:00 UTC 2022

The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma.

Scientific reports

Moriyama M,Kanda T,Midorikawa Y,Matsumura H,Masuzaki R,Nakamura H,Ogawa M,Matsuoka S,Shibata T,Yamazaki M,Kuroda K,Nakayama H,Higaki T,Kanemaru K,Miki T,Sugitani M,Takayama T

Mon Nov 28 00:00:00 UTC 2022

Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21.

FEBS open bio

Kawamura E,Matsubara T,Daikoku A,Deguchi S,Kinoshita M,Yuasa H,Urushima H,Odagiri N,Motoyama H,Kotani K,Kozuka R,Hagihara A,Fujii H,Uchida-Kobayashi S,Tanaka S,Takemura S,Iwaisako K,Enomoto M,Taguchi YH,Tamori A,Kubo S,Ikeda K,Kawada N

Thu Dec 01 00:00:00 UTC 2022

CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma.

Frontiers in oncology

Cai C,Zhang Y,Hu X,Hu W,Yang S,Qiu H,Chu T

Wed Apr 27 00:00:00 UTC 2022

CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma.

Frontiers in oncology

Cai C,Zhang Y,Hu X,Hu W,Yang S,Qiu H,Chu T

Wed Apr 27 00:00:00 UTC 2022

IP₆-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.

Nature communications

Lin H,Yan Y,Luo Y,So WY,Wei X,Zhang X,Yang X,Zhang J,Su Y,Yang X,Zhang B,Zhang K,Jiang N,Chow BKC,Han W,Wang F,Rao F

Wed Apr 28 00:00:00 UTC 2021

Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.

Journal of medicinal chemistry

Zhou W,Ma L,Ding L,Guo Q,He Z,Yang J,Qiao H,Li L,Yang J,Yu S,Zhao L,Wang S,Liu HM,Suo Z,Zhao W

Thu Jun 13 00:00:00 UTC 2019

RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.

Oncotarget

Fei L,Ma Y,Zhang M,Liu X,Luo Y,Wang C,Zhang H,Zhang W,Han Y

Tue Jun 20 00:00:00 UTC 2017

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Nature

Lin HK,Chen Z,Wang G,Nardella C,Lee SW,Chan CH,Yang WL,Wang J,Egia A,Nakayama KI,Cordon-Cardo C,Teruya-Feldstein J,Pandolfi PP

Thu Mar 18 00:00:00 UTC 2010

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Nature

Lin HK,Chen Z,Wang G,Nardella C,Lee SW,Chan CH,Yang WL,Wang J,Egia A,Nakayama KI,Cordon-Cardo C,Teruya-Feldstein J,Pandolfi PP

Thu Mar 18 00:00:00 UTC 2010

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Nature

Lin HK,Chen Z,Wang G,Nardella C,Lee SW,Chan CH,Yang WL,Wang J,Egia A,Nakayama KI,Cordon-Cardo C,Teruya-Feldstein J,Pandolfi PP

Thu Mar 18 00:00:00 UTC 2010

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Nature

Lin HK,Chen Z,Wang G,Nardella C,Lee SW,Chan CH,Yang WL,Wang J,Egia A,Nakayama KI,Cordon-Cardo C,Teruya-Feldstein J,Pandolfi PP

Thu Mar 18 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: CDT1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP

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Gene Aliases: CDT1; DUP; RIS2

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UniProt ID: (Human) Q9H211

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Entrez Gene ID: (Human) 81620

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Function(s)

DNA binding protein binding DNA metabolism protein

Process(es)

DNA replication checkpoint G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle DNA replication regulation of DNA-dependent DNA replication initiation regulation of nuclear cell cycle DNA replication

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDT1 Polyclonal Antibody

CDT1 Antibody (14382-1-AP) in WB

Product Details

14382-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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