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Proteintech
CDT1 Polyclonal Antibody
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Product Details
14382-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDT1 Fusion Protein Ag5810 (195-546 aa encoded by BC000137)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EMFRSMDTI VGMLHNRSET PTFAKVQRGV QDMMRRRFEE RNVGQIKTVY PASYRFRQER SVPTFKDGTR RSDYQLTIEP LLEQEADGAA PQLTASRLLQ RRQIFSQKLV EHVKEHHKAF LASLSPAMVV PEDQLTRWHP RFNVDEVPDI EPAALPQPPA TEKLTTAQEV LARARNLISP RMEKALSQLA LRSAAPSSPG SPRPALPATP PATPPAASPS ALKGVSQDLL ERIRAKEAQK QLAQMTRCPE QEQRLQRLER LPELARVLRS VFVSERKPAL SMEVACARMV GSCCTIMSPG EMEKHLLLLS ELLPDWLSLH RIRTDTYVKL DKAADLAHIT ARLAHQTRAE EGL (195-546 aa encoded by BC000137)
Target Information
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDT1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP
Gene Aliases: CDT1; DUP; RIS2
UniProt ID: (Human) Q9H211
Entrez Gene ID: (Human) 81620
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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