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Invitrogen
CDX1 Polyclonal Antibody, HRP
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Product Details
PA5-23060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A genomic peptide made to an internal region of the human Cdx1 protein (within residues 30-150).
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Amount
55 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CDX1, or caudal type homeobox 1, is a gene encoding a homeodomain transcription factor that plays a significant role in the development and differentiation of intestinal epithelial cells. CDX1 is expressed in the intestinal crypts, where it is integral to the Wnt/B-catenin signaling pathway, crucial for cell proliferation. Interestingly, while CDX1 expression is initially active, its expression is often silenced as colon cancer progresses in humans, suggesting a complex role in tumor biology. The CDX1 protein functions as a transcriptional regulator that influences proliferation and differentiation, expressing early during intestinal development. In mice, it is involved in the development of the posterior embryo and is associated with abnormal differentiation in metaplastic and neoplastic tissues, providing insight into intestinal-type gastric adenocarcinoma progression. CDX1 is related to other vertebrate Cdx genes such as Cdx2 and Cdx4, which are homologues of the Drosophila caudal gene and are also implicated in embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caudal type homeo box 1; caudal type homeo box transcription factor 1; caudal type homeobox transcription factor 1; Caudal-type homeobox protein 1; caudal-type homeobox protein CDX1; Homeobox protein CDX-1
Gene Aliases: Cdx; Cdx-1; CDX1
UniProt ID: (Human) P47902, (Mouse) P18111
Entrez Gene ID: (Human) 1044, (Mouse) 12590
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
methyl-CpG binding
sequence-specific double-stranded DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
sequence-specific DNA binding
homeodomain transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
pattern specification process
embryonic pattern specification
organ morphogenesis
anterior/posterior axis specification
anterior/posterior pattern specification
regulation of somitogenesis
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
bone morphogenesis
transcription from RNA polymerase II promoter
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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