This antibody is predicted to react with canine, mouse and rat based on sequence homology.
The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription .
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Protein Aliases: caudal type homeo box transcription factor 2; caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX-3; CDX2; CDX3; HGNC:1806; Homeobox protein CDX-2; homeobox protein miniCDX2
Gene Aliases: CDX-3; CDX2; CDX2/AS; CDX3
UniProt ID: (Human) Q99626
Entrez Gene ID: (Human) 1045