PA5-27712 targets BMPR1B in WB applications and shows reactivity with Human samples.
The PA5-27712 immunogen is recombinant fragment corresponding to a region within amino acids 238 and 502 of Human BMPR1B.
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This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.
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Protein Aliases: activin receptor-like kinase 6; ALK6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase
Gene Aliases: ALK-6; ALK6; AMDD; BDA1D; BDA2; BMPR1B; CDw293
UniProt ID: (Human) O00238
Entrez Gene ID: (Human) 658