Recommended positive controls: 293T, Neuro2A, C8D30, NIH-3T3, human BMPR1B-transfected 293T, Rat2.
Predicted reactivity: Mouse (98%), Rat (98%), Dog (98%), Pig (98%), Chicken (96%), Sheep (98%), Rhesus Monkey (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
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Protein Aliases: Activin receptor-like kinase 6; ALK-6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein binding serine/threonine kinase receptor; bone morphogenetic protein receptor IB; bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase; Serine/threonine-protein kinase receptor R6; SKR6
Gene Aliases: Acvrlk6; AI385617; ALK-6; ALK6; AMDD; AV355320; BDA1D; BDA2; BMP15; BMPR-1B; BMPR-IB; BMPR1B; BMPRIB; CDw293; CFK-43a; SKR6
Molecular Function: serine/threonine protein kinase receptor