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Product Details
PA5-27712
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 238 and 502 of Human BMPR1B
Conjugate
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2545188
Product Specific Information
Recommended positive controls: 293T, Neuro2A, C8D30, NIH-3T3, human BMPR1B-transfected 293T, Rat2.
Predicted reactivity: Mouse (98%), Rat (98%), Dog (98%), Pig (98%), Chicken (96%), Sheep (98%), Rhesus Monkey (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activin receptor-like kinase 6; ALK-6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein binding serine/threonine kinase receptor; bone morphogenetic protein receptor IB; bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase; Serine/threonine-protein kinase receptor R6; SKR6
Gene Aliases: Acvrlk6; AI385617; ALK-6; ALK6; AMDD; AV355320; BDA1D; BDA2; BMP15; BMPR-1B; BMPR-IB; BMPR1B; BMPRIB; CDw293; CFK-43a; SKR6
UniProt ID: (Human) B4DSV1, (Mouse) P36898
Entrez Gene ID: (Bovine) 407128, (Human) 658, (Mouse) 12167, (Rat) 310914
Molecular Function:
serine/threonine protein kinase receptor
skeletal system development
cartilage condensation
ovarian cumulus expansion
eye development
chondrocyte development
protein phosphorylation
inflammatory response
dorsal/ventral pattern formation
signal transduction by protein phosphorylation
proteoglycan biosynthetic process
positive regulation of bone mineralization
BMP signaling pathway
retinal ganglion cell axon guidance
positive regulation of chondrocyte differentiation
limb morphogenesis
ovulation cycle
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
retina development in camera-type eye
endochondral bone morphogenesis
positive regulation of cartilage development
cellular response to BMP stimulus
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of chondrocyte proliferation
chondrocyte differentiation
estrogen biosynthetic process
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
phosphorylation
cell differentiation
camera-type eye development
cartilage development
biological_process
glycoprotein binding
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
SMAD binding
metal ion binding
nucleotide binding
protein kinase activity
transforming growth factor beta-activated receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
Performance Guarantee
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