Invitrogen

CEACAM1/CEACAM5 Recombinant Rabbit Monoclonal Antibody (BLR032F)

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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
CEACAM1/CEACAM5 Recombinant Rabbit Monoclonal Antibody (BLR032F)

Product Details

MA5-44259

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Immunoprecipitation (IP)

20 µL/1 mg lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR032F

Immunogen

Recombinant protein representing the extracellular domain of human CEACAM1 (residues 35-433).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

50 µg/mL

Purification

purified

Storage buffer

BBS, pH 8.2, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2926389

Product Specific Information

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

Target Information

Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 5; CD66a; CD66a antigen; CD66e; CEA; CEA cell adhesion molecule 1; CEA cell adhesion molecule 5; Cell adhesion molecule CEACAM1; Cell adhesion molecule CEACAM5; Meconium antigen 100; pan CEACAM; sCD66e; soluble CD66e

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Gene Aliases: BGP; BGP1; BGPI; CD66e; CEA; CEACAM1; CEACAM5

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UniProt ID: (Human) P13688, (Human) P06731

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Entrez Gene ID: (Human) 634, (Human) 1048

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Function(s)
molecular_function actin binding protein binding bile acid transmembrane transporter activity kinase binding protein phosphatase binding filamin binding protein homodimerization activity protein dimerization activity protein tyrosine kinase binding GPI anchor binding identical protein binding
Process(es)
angiogenesis regulation of cell growth blood vessel development negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of protein kinase activity cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules integrin-mediated signaling pathway regulation of endothelial cell migration regulation of phosphatidylinositol 3-kinase signaling bile acid and bile salt transport cell migration regulation of cell migration negative regulation of granulocyte differentiation negative regulation of interleukin-1 production cellular response to insulin stimulus common myeloid progenitor cell proliferation insulin receptor internalization granulocyte colony-stimulating factor signaling pathway regulation of epidermal growth factor receptor signaling pathway negative regulation of vascular permeability negative regulation of cytotoxic T cell degranulation wound healing, spreading of cells regulation of endothelial cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of T cell receptor signaling pathway leukocyte migration negative regulation of lipid biosynthetic process regulation of blood vessel remodeling regulation of ERK1 and ERK2 cascade negative regulation of platelet aggregation cell-cell adhesion insulin catabolic process regulation of homophilic cell adhesion regulation of sprouting angiogenesis negative regulation of hepatocyte proliferation positive regulation of vasculogenesis negative regulation of myotube differentiation homotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of anoikis
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