CEL catalyzes fat and vitamin absorption. CEL acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.
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Protein Aliases: BAL; Bile salt stimulated lipase; Bile salt-activated lipase; bile salt-dependent lipase, oncofetal isoform; Bile salt-stimulated lipase; BSDL; BSSL; Bucelipase; carboxyl ester hydrolase; Carboxyl ester lipase; carboxyl ester lipase (bile salt-stimulated lipase); CEase; CEL; CELL; Cholesterol esterase; FAPP; fetoacinar pancreatic protein; LIPA; lysophospholipase, pancreatic; MODY8; Pancreatic lysophospholipase; Sterol esterase
Gene Aliases: 1810036E18Rik; BAL; BSDL; BSSL; CEase; Cel; CELL; FAP; FAPP; Lip1; LIPA; MODY8
UniProt ID: (Mouse) Q64285