Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
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Protein Aliases: BAL; Bile salt-activated lipase; bile salt-dependent lipase, oncofetal isoform; Bile salt-stimulated lipase; BSSL; bucelipase; carboxyl ester hydrolase; Carboxyl ester lipase; carboxyl ester lipase (bile salt-stimulated lipase); Cholesterol esterase; fetoacinar pancreatic protein; lysophospholipase, pancreatic; Pancreatic lysophospholipase; Sterol esterase
Gene Aliases: 1810036E18Rik; BAL; BSDL; BSSL; CEase; Cel; CELL; FAP; FAPP; Lip1; LIPA; MODY8
UniProt ID: (Mouse) Q64285