Immunogen sequence: LEYPMLHYVG FVPVIDGDFI PADPINLYAN AADIDYIAGT NNMDGHIFAS IDMPAINKGN KKVTEEDFYK LVSEFTITKG LRGAKTTFDV YTESWAQDPS QENKKKTVVD FETDVLFLVP TEIALAQH
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 72%.
CEL catalyzes fat and vitamin absorption. CEL acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Protein Aliases: bile salt-dependent lipase, oncofetal isoform; BSDL; bucelipase; carboxyl ester hydrolase; Carboxyl ester lipase (bile salt-stimulated lipase); CEase; CELL; cholesterol esterase; FAPP; fetoacinar pancreatic protein; LIPA; lysophospholipase, pancreatic; MODY8; sterol esterase
Gene Aliases: BAL; BSDL; BSSL; CEase; CELL; FAP; FAPP; LIPA; MODY8
Entrez Gene ID: (Human) 1056