Immunogen sequence: MGPRRRSRK PEAPRRRSPS PTPTPGPSRR GPSLGASSHQ HSRRRQGWLK EIRKLQKSTH (1-59 aa encoded by BC002703 )
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
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Protein Aliases: CENP A; CENP-A; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; centromere-specific histone; Histone H3-like centromeric protein A
Gene Aliases: CenH3; CENP-A; CENPA
UniProt ID: (Human) P49450
Entrez Gene ID: (Human) 1058
Molecular Function: chromatin/chromatin-binding, or -regulatory protein histone