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Human CENPA shares 71.6% amino acid (aa) sequence identity with mouse CENPA.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CENP A; CENP-A; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; centromere-specific histone; Histone H3-like centromeric protein A
Gene Aliases: CenH3; CENP-A; CENPA; RGD1563607
UniProt ID: (Human) P49450
Entrez Gene ID: (Human) 1058, (Rat) 298850
Molecular Function:
DNA binding protein
histone
nucleic acid binding
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