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Proteintech
CENPJ Polyclonal Antibody
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Product Details
11517-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CENPJ Fusion Protein Ag2078 (1033-1338 aa encoded by BC024209)
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RENTDLREE IKVMERFRLD AWKRAEAIES SLEVEKKDKL ANTSVRFQNS QISSGTQVEK YKKNYLPMQG NPPRRSKSAP PRDLGNLDKG QAASPREPLE PLNFPDPEYK EEEEDQDIQG EISHPDGKVE KVYKNGCRVI LFPNGTRKEV SADGKTITVT FFNGDVKQVM PDQRVIYYYA AAQTTHTTYP EGLEVLHFSS GQIEKHYPDG RKEITFPDQT VKNLFPDGQE ESIFPDGTIV RVQRDGNKLI EFNNGQRELH TAQFKRREYP DGTVKTVYAN GHQETKYRSG RIRVKDKEGN VLMDTEL (1033-1338 aa encoded by BC024209)
Target Information
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CENP-J; Centromere protein J; Centrosomal P4.1-associated protein; LAG-3-associated protein; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; microcephaly
Gene Aliases: 4932437H03Rik; BM032; CENP-J; CENPJ; CPAP; Gm81; LAP; LIP1; MCPH6; Sas-4; Sas4; SASS4; SCKL4
UniProt ID: (Human) Q9HC77, (Mouse) Q569L8
Entrez Gene ID: (Human) 55835, (Rat) 305909, (Mouse) 219103
G2/M transition of mitotic cell cycle
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
microtubule nucleation
centriole replication
regulation of centriole replication
microtubule polymerization
cell division
centriole elongation
astral microtubule nucleation
positive regulation of JAK-STAT cascade
regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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