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Invitrogen
CETP Polyclonal Antibody
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Product Details
PA5-113950
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human CETP
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KKLFLSLLDF QITPKTVSNL TESSSESVQS FLQSMITAVG IPEVMSRLEV
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Human: 100%
Target Information
It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BPI fold containing family F; Cholesteryl ester transfer protein; cholesteryl ester transfer protein plasma; cholesteryl ester transfer protein precursor; Lipid transfer protein I; unnamed protein product
Gene Aliases: BPIFF; CETP; HDLCQ10
UniProt ID: (Human) P11597
Entrez Gene ID: (Human) 1071
lipid metabolic process
triglyceride metabolic process
lipid transport
steroid metabolic process
cholesterol metabolic process
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol efflux
phospholipid transport
cholesterol transport
positive regulation of cholesterol transport
triglyceride transport
very-low-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
cholesterol homeostasis
reverse cholesterol transport
phosphatidylcholine metabolic process
lipid homeostasis
phospholipid homeostasis
triglyceride homeostasis
positive regulation of phospholipid transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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