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CETP Antibody (PA5-89297) in IHC (P)
Immunohistochemistry analysis of CETP in paraffin-embedded human stomach. Samples were incubated with CETP Polyclonal antibody (Product # PA5-89297). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol. 40x lens.
Product Details
PA5-89297
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 300-493 of human CETP (NP_0000692)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805475
Product Specific Information
Immunogen sequence: LMLSLMGDEF KAVLETWGFN TNQEIFQEVV GGFPSQAQVT VHCLKMPKIS CQNKGVVVNS SVMVKFLFPR PDQQHSVAYT FEEDIVTTVQ ASYSKKKLFL SLLDFQITPK TVSNLTESSS ESVQSFLQSM ITAVGIPEVM SRLEVVFTAL MNSKGVSLFD IINPEIITRD GFLLLQMDFG FPEHLLVDFL QSLS; Positive Samples: A-549, HepG2, A375, Mouse liver, Rat liver; Cellular Location: extracellular space
Target Information
It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BPI fold containing family F; Cholesteryl ester transfer protein; cholesteryl ester transfer protein plasma; cholesteryl ester transfer protein, plasma; Lipid transfer protein I
Gene Aliases: BPIFF; CETP; HDLCQ10
UniProt ID: (Human) P11597
Entrez Gene ID: (Human) 1071
triglyceride metabolic process
lipid transport
receptor-mediated endocytosis
cholesterol metabolic process
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol efflux
phospholipid transport
cholesterol transport
triglyceride transport
very-low-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
phosphatidylcholine metabolic process
lipid homeostasis
phospholipid homeostasis
triglyceride homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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