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HES1 Monoclonal Antibody (OTI4H1), TrueMAB™

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HES1 Monoclonal Antibody (OTI4H1), TrueMAB™

Product Details

CF500114

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI4H1

Immunogen

Recombinant protein expressed in E.coli corresponding to amino acids 1-280 of human HES1
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: class B basic helix-loop-helix protein 39; FLJ20408; hairy homolog; Hairy-like; hairy-like protein; HES1; unnamed protein product

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Gene Aliases: bHLHb39; HES-1; HHL; HRY

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UniProt ID: (Human) Q14469

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Entrez Gene ID: (Human) 3280

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding protein binding JUN kinase binding identical protein binding protein homodimerization activity histone deacetylase binding HLH domain binding sequence-specific DNA binding macromolecular complex binding protein dimerization activity chaperone binding RNA polymerase II sequence-specific DNA binding transcription factor binding E-box binding N-box binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter embryonic heart tube morphogenesis outflow tract morphogenesis ventricular septum development regulation of transcription, DNA-templated Notch signaling pathway nervous system development positive regulation of cell proliferation anterior/posterior pattern specification positive regulation of gene expression negative regulation of gene expression negative regulation of neuron projection development forebrain radial glial cell differentiation neuron differentiation hair cell differentiation aorta morphogenesis ascending aorta morphogenesis positive regulation of tyrosine phosphorylation of STAT protein regulation of protein complex assembly response to alkaloid positive regulation of DNA binding negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of mitotic cell cycle, embryonic regulation of JAK-STAT cascade positive regulation of JAK-STAT cascade thymus development positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation artery morphogenesis regulation of neurogenesis negative regulation of neurogenesis negative regulation of glial cell proliferation ventricular septum morphogenesis ureteric bud morphogenesis labyrinthine layer blood vessel development pharyngeal arch artery morphogenesis protein-containing complex assembly cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to fatty acid glomerulus vasculature development comma-shaped body morphogenesis S-shaped body morphogenesis renal interstitial fibroblast development metanephric nephron tubule morphogenesis negative regulation of calcium ion import response to thyroid hormone vascular smooth muscle cell development neuronal stem cell population maintenance response to Aroclor 1254 cellular response to nerve growth factor stimulus negative regulation of stem cell differentiation negative regulation of pro-B cell differentiation negative regulation of forebrain neuron differentiation negative regulation of inner ear receptor cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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