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OriGene
GBA3 Monoclonal Antibody (OTI3E8), TrueMAB™
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Product Details
CF502516
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3E8
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-150 and 370-469 of human GBA3 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides. GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytosolic beta-glucosidase; Cytosolic beta-glucosidase-like protein 1; Cytosolic galactosylceramidase; Cytosolic GCase; Cytosolic glucosylceramidase; Cytosolic glycosylceramidase; Glucosidase beta acid 3; glucosidase, beta, acid 3 (cytosolic); Glucosylceramidase beta 3; glycosyl hydrolase; Klotho-related protein; KLrP; unnamed protein product
Gene Aliases: CBG; CBGL1; GBA3; GLUC; KLRP
UniProt ID: (Human) Q9H227
Entrez Gene ID: (Human) 57733
carbohydrate metabolic process
lipid metabolic process
glucosylceramide catabolic process
galactosylceramide catabolic process
oligosaccharide catabolic process
carbohydrate catabolic process
glycoside catabolic process
glycosylceramide catabolic process
glycosphingolipid catabolic process
protein stabilization
beta-glucoside catabolic process
positive regulation of exo-alpha-sialidase activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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