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OriGene
TIMP2 Monoclonal Antibody (OTI1A6), TrueMAB™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CF504017
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1A6
Immunogen
Full length human recombinant protein of human TIMP2 produced in HEK293T cell.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: metalloproteinase inhibitor precursor; metalloproteinase-2 inhibitor precursor; testicular secretory protein Li 57; testicular tissue inhibitor of metalloproteases-2; TIMP 2; TIMP-2; tissue inhibitor of matrix metalloproteinase-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase-2; tissue inhibitor of metalloproteinases 2; unnamed protein product
Gene Aliases: CSC-21K; D11Bwg1104e; DDC8; Timp-2
UniProt ID: (Dog) Q9TTY1, (Human) P16035, (Rat) P30121
Entrez Gene ID: (Dog) 403633, (Human) 7077, (Mouse) 21858, (Rat) 29543
response to hormone
response to cytokine
negative regulation of proteolysis
negative regulation of membrane protein ectodomain proteolysis
negative regulation of metallopeptidase activity
negative regulation of cell proliferation
regulation of Rap protein signal transduction
regulation of MAPK cascade
positive regulation of MAPK cascade
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
spermatogenesis
response to xenobiotic stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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