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TICAM1 Monoclonal Antibody (OTI1G7), TrueMAB™

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TICAM1 Monoclonal Antibody (OTI1G7), TrueMAB™

Product Details

CF800679

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI1G7

Immunogen

Human recombinant protein fragment corresponding to amino acids 120-420 of human TICAM1 produced in E.coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hCG_39321; HSD34; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; RNF36; TI; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; toll like receptor adaptor molecule 1; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

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Gene Aliases: IIAE6; MyD88-3; PRVTIRB; TICAM-1; TICAM1; TRIF

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UniProt ID: (Human) Q8IUC6

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Entrez Gene ID: (Human) 148022

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Function(s)
protein binding protein kinase binding signaling adaptor activity binding, bridging
Process(es)
toll-like receptor signaling pathway macrophage activation involved in immune response immune system process positive regulation of myeloid dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway nitric oxide biosynthetic process apoptotic process inflammatory response signal transduction cell surface receptor signaling pathway positive regulation of autophagy positive regulation of gene expression positive regulation of B cell proliferation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway B cell proliferation B cell activation positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly response to exogenous dsRNA innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of B cell activation defense response to virus positive regulation of macrophage cytokine production cellular response to lipopolysaccharide apoptotic signaling pathway cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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