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OriGene
WNT3 Monoclonal Antibody (OTI1C5), TrueMAB™
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Product Details
CF801734
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1C5
Immunogen
Human recombinant protein fragment corresponding to amino acids 128-355 of human WNT3 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
WNT3, part of the WNT gene family, consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC131950; MGC138321; MGC138323; Proto-oncogene Int-4 homolog; Proto-oncogene Wnt-3; wingless-type MMTV integration site family, member 3; WNT-3 proto-oncogene protein
Gene Aliases: INT4; TETAMS; WNT3
UniProt ID: (Human) P56703
Entrez Gene ID: (Human) 7473
cell morphogenesis
mesoderm formation
gamete generation
axon guidance
anatomical structure morphogenesis
anterior/posterior axis specification
dorsal/ventral axis specification
anterior/posterior pattern specification
gene expression
positive regulation of gene expression
Wnt signaling pathway
positive regulation of Wnt signaling pathway
neuron differentiation
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
cell fate commitment
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
animal organ development
anatomical structure formation involved in morphogenesis
positive regulation of collateral sprouting in absence of injury
system development
negative regulation of axon extension involved in axon guidance
regulation of neurogenesis
Spemann organizer formation at the anterior end of the primitive streak
canonical Wnt signaling pathway
limb development
limb bud formation
head morphogenesis
mammary gland epithelium development
cellular response to retinoic acid
stem cell proliferation
midbrain dopaminergic neuron differentiation
regulation of mesenchymal stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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