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OriGene
NPR1 Monoclonal Antibody (OTI7H7), TrueMAB™
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FIGURE: 1 / 1
NPR1 Antibody (CF805600) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NPR1 (RC209267, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-NPR1. Positive lysates LY424461 (100 µg) and LC424461 (20 µg) can be purchased separately from OriGene.
Product Details
CF805600
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI7H7
Immunogen
Human recombinant protein fragment corresponding to amino acids 746-1006 of human NPR1 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP, respectively).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANP-A; ANPR-A; ARABIDOPSIS NONEXPRESSER OF PR GENES 1; AT1G64280; ATNPR1; Atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor guanylate cyclase; Atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; F15H21.6; F15H21_6; GC-A; Guanylate cyclase A; natriuretic peptide A type receptor; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NIM1; NON-INDUCIBLE IMMUNITY 1; NONEXPRESSER OF PR GENES 1; NPR-A; REGULATORY PROTEIN NPR1; SAI1; SALICYLIC ACID INSENSITIVE 1; testicular tissue protein Li 20; unnamed protein product
Gene Aliases: ANPa; ANPRA; GUC2A; GUCY2A; NPR1; NPRA
UniProt ID: (Human) P16066
Entrez Gene ID: (Human) 4881
cGMP biosynthetic process
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
G-protein coupled receptor signaling pathway
body fluid secretion
blood circulation
regulation of blood pressure
cyclic nucleotide biosynthetic process
positive regulation of cGMP-mediated signaling
negative regulation of angiogenesis
cGMP-mediated signaling
negative regulation of cell growth
intracellular signal transduction
positive regulation of urine volume
positive regulation of renal sodium excretion
dopamine metabolic process
regulation of vascular permeability
negative regulation of smooth muscle cell proliferation
regulation of blood vessel diameter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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