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OriGene
CHMP5 Monoclonal Antibody (OTI2E6), TrueMAB™
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FIGURE: 1 / 5
CHMP5 Antibody (CF808543) in IHC (P)
Immunohistochemical staining of paraffin-embedded human prostate tissue within the normal limits using anti-CHMP5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808543)(1:150)
Product Details
CF808543
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2E6
Immunogen
Full length human recombinant protein of human CHMP5 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein family. These proteins are components of ESCRT-III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies. Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis-related protein PNAS-2; Charged multivesicular body protein 5; chromatin modifying protein 5; Chromatin-modifying protein 5; HGNC:26942; hVps60; likely ortholog of H. sapiens SNF7 domain containing 2; small protein with inherent killing effect; SNF7 domain containing 2; SNF7 domain-containing protein 2; unnamed protein product; Vacuolar protein sorting-associated protein 60; Vps60
Gene Aliases: 2210412K09Rik; AW545668; C9orf83; CGI-34; CHMP5; HSPC177; PNAS-114; PNAS-2; RGD1305968; SNF7DC2; Spike; Vps60
UniProt ID: (Human) Q9NZZ3, (Mouse) Q9D7S9, (Rat) Q5RK31
Entrez Gene ID: (Human) 51510, (Mouse) 76959, (Rat) 297995
plasma membrane repair
regulation of receptor recycling
membrane budding
autophagy
nucleus organization
vacuolar transport
lysosome organization
mitotic metaphase plate congression
endosome to lysosome transport
regulation of centrosome duplication
protein transport
erythrocyte differentiation
nuclear envelope reassembly
late endosome to vacuole transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding
viral budding from plasma membrane
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
cellular response to lipopolysaccharide
cellular response to muramyl dipeptide
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
ESCRT III complex disassembly
cell separation after cytokinesis
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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