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This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: complement component factor h-like 1; complement factor H-related 1; complement factor H-related 1 pseudogene; complement factor H-related protein; Complement factor H-related protein 1; FHR-1; H factor (complement)-like 1; H factor (complement)-like 2; H factor-like protein 1; H-factor-like 1; H36
Gene Aliases: AI194696; CFHL; CFHL1; CFHL1P; CFHR1; CFHR1P; CFHRB; FHR1; H36-1; H36-2; HFL1; HFL2
UniProt ID: (Human) Q03591
Entrez Gene ID: (Human) 3078, (Rat) 289057, (Mouse) 50702
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