Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
10394-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CFLAR/FLIP Fusion Protein Ag0593 (31-184 aa encoded by BC001602)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.72 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: DVVPPNVRD LLDILRERGK LSVGDLAELL YRVRRFDLLK RILKMDRKAV ETHLLRNPHL VSDYRVLMAE IGEDLDKSDV SSLIFLMKDY MGRGKISKEK SFLDLVVELE KLNLVAPDQL DLLEKCLKNI HRIDLKTKIQ KYKQSVQGAG TSYRN (31-184 aa encoded by B C001602)
Target Information
FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-FLIP; CASH; CASP8 and FADD-like apoptosis regulator; CASP8 and FADD-like apoptosis regulator subunit p12; CASP8 and FADD-like apoptosis regulator subunit p43; Caspase homolog; Caspase-eight-related protein; Caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory protein; CLARP; FADD-like antiapoptotic molecule 1; FLAME-1; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; testis secretory sperm-binding protein Li 233m; Usurpin; usurpin beta
Gene Aliases: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CFLAR; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT
UniProt ID: (Human) O15519
Entrez Gene ID: (Human) 8837
Molecular Function:
protease
proteolysis
apoptotic process
skeletal muscle tissue development
skeletal muscle atrophy
regulation of skeletal muscle satellite cell proliferation
skeletal myofibril assembly
viral process
negative regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
skeletal muscle tissue regeneration
positive regulation of NF-kappaB transcription factor activity
regulation of necroptotic process
execution phase of apoptosis
negative regulation of myoblast fusion
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support