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Proteintech

CFLAR/FLIP Polyclonal Antibody

11 References
View all (32) FLIP antibodies

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CFLAR/FLIP Polyclonal Antibody

Product Details

10394-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 9 publications 9 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
-

Immunoprecipitation (IP)

0.5-4.0 µg
-

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CFLAR/FLIP Fusion Protein Ag0593 (31-184 aa encoded by BC001602)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.72 mg/mL

Amount

108 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DVVPPNVRD LLDILRERGK LSVGDLAELL YRVRRFDLLK RILKMDRKAV ETHLLRNPHL VSDYRVLMAE IGEDLDKSDV SSLIFLMKDY MGRGKISKEK SFLDLVVELE KLNLVAPDQL DLLEKCLKNI HRIDLKTKIQ KYKQSVQGAG TSYRN (31-184 aa encoded by B C001602)

Target Information

FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: c-FLIP; CASH; CASP8 and FADD-like apoptosis regulator; Caspase homolog; Caspase-eight-related protein; Caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory protein; CLARP; DED-caspase homologue; FADD-like antiapoptotic molecule 1; FLAME-1; FLIP-L; apoptosis inhibitor; FLIP-S; apoptosis inhibitor; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; testis secretory sperm-binding protein Li 233m; unnamed protein product; Usurpin; usurpin beta

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Gene Aliases: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CFLAR; cFLIP; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT

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UniProt ID: (Human) O15519

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Entrez Gene ID: (Human) 8837

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Function(s)
protease binding cysteine-type endopeptidase activity death receptor binding protein binding enzyme activator activity cysteine-type peptidase activity macromolecular complex binding
Process(es)
response to hypoxia proteolysis apoptotic process skeletal muscle tissue development extrinsic apoptotic signaling pathway via death domain receptors negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development skeletal muscle atrophy regulation of skeletal muscle satellite cell proliferation skeletal myofibril assembly macrophage differentiation cellular response to insulin stimulus response to testosterone regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling skeletal muscle tissue regeneration positive regulation of neuron apoptotic process regulation of necroptotic process positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to dexamethasone stimulus cellular response to nitric oxide positive regulation of glomerular mesangial cell proliferation negative regulation of myoblast fusion negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extracellular matrix organization negative regulation of reactive oxygen species biosynthetic process negative regulation of cellular response to transforming growth factor beta stimulus negative regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process positive regulation of hepatocyte proliferation negative regulation of extrinsic apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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