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Invitrogen
CFTR Polyclonal Antibody
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FIGURE: 1 / 3
CFTR Antibody (PA5149873) in IHC (P)
Immunohistochemistry analysis of CFTR in paraffin-embedded Human Kidney tissue. Samples were incubated with CFTR Polyclonal (Product # PA5149873) antibody using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5149873
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) (Gln359-Ser858)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP Binding Cassette Superfamily C Member 7 (ABCC7); ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; CFTR; Channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulating; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator isoform; membrane channel; tcag7.78; TNR CFTR
Gene Aliases: ABC35; ABCC7; CF; CFTR; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR
UniProt ID: (Human) P13569, (Pig) Q6PQZ2
Entrez Gene ID: (Human) 1080, (Pig) 403154
nucleotide binding
chloride channel activity
channel-conductance-controlling ATPase activity
protein binding
ATP binding
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
isomerase activity
ATPase activity
chloride channel regulator activity
chloride channel inhibitor activity
enzyme binding
PDZ domain binding
anion transmembrane-transporting ATPase activity
chaperone binding
14-3-3 protein binding
Sec61 translocon complex binding
ABC-type transporter activity
ATP-binding cassette (ABC) transporter
cholesterol biosynthetic process
ion transport
chloride transport
water transport
vesicle docking involved in exocytosis
bicarbonate transport
cholesterol transport
ion transmembrane transport
response to endoplasmic reticulum stress
transepithelial water transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of exocytosis
sperm capacitation
multicellular organismal water homeostasis
intracellular pH elevation
establishment of localization in cell
transmembrane transport
membrane hyperpolarization
regulation of biological quality
positive regulation of enamel mineralization
cellular response to cAMP
amelogenesis
inorganic ion transmembrane transport
chloride transmembrane transport
positive regulation of voltage-gated chloride channel activity
cellular response to forskolin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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