CHAT is known to be present exclusively in the cytoplasm of cholinergic neurons and anti-CHAT antibody has been considered as the best marker for cholinergic neurons.
Immunogen sequence: SDTHRALQL LHGGGYSKNG ANRWYDKSLQ FVVGRDGTCG VVCEHSPFDG IVLVQCTEHL LKHMTQSSRK LIRADSVSEL PAPRRLRWKC SPEIQGHLAS SAEKLQRIVK NLDFIVYKFD NYGKTFIKKQ KCSPDAFIQV ALQLAFYRLH RRLVPTYESA SIRRFQEGRV DNIRSATPEA LAFVRAVTDH KAAVPASEKL LLLKDAIRAQ TAYTVMAITG MAIDNHLLAL RELARAMCKE LPEMFMDETY LMSNRFVLST SQVPTTTEMF CCYGPVVPNG YGACYNPQPE TILFCISSFH SCKETSSSKF AKAVEESLID MRDLCSLLPP TESKPLATKE KATRPSQGHQ P (399-748 aa encoded by BC130617)
ChAT catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
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Protein Aliases: acetyl CoA; acetyl CoA:choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase; Choline O-acetyltransferase
Gene Aliases: B230380D24Rik; CHAT; CHOACTASE; CMS1A; CMS1A2; CMS6
UniProt ID: (Human) P28329
Molecular Function: acyltransferase