This antibody is predicted to react with bovine, canine, ovine and rat based on sequence homology.
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Coiled-coil-helix-coiled-coil-helix domain-containing protein 3; coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial; FLJ20420; MICOS complex subunit MIC19; mitochondrial inner membrane organizing system 3; protein phosphatase 1, regulatory subunit 22
Gene Aliases: CHCHD3; MIC19; MINOS3; PPP1R22
UniProt ID: (Human) Q9NX63
Entrez Gene ID: (Human) 54927