Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Antibody detects endogenous levels of total CHCHD6.
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: coiled coil helix cristae morphology 1; coiled coil helix cristae morphology protein 1; coiled-coil-helix cristae morphology 1; Coiled-coil-helix cristae morphology protein 1; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; MICOS complex subunit MIC25; protein phosphatase 1, regulatory subunit 23
Gene Aliases: CHCHD6; CHCM1; MIC25; PPP1R23
UniProt ID: (Human) D6RIB4, (Rat) D4A7N1
Entrez Gene ID: (Human) 84303, (Rat) 297436
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support