Peptide sequence: DALPAAEGGS RDQEEGKNHM YLFEGKDYSK EPSKEDRKSF EQLVNLQKTL
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]).
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Protein Aliases: amplified in liver cancer 1; Amplified in liver cancer protein 1; chromodomain helicase DNA binding protein 1-like; Chromodomain-helicase-DNA-binding protein 1-like
Gene Aliases: ALC1; CHD1L; CHDL
UniProt ID: (Human) Q86WJ1
Entrez Gene ID: (Human) 9557