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Bethyl Laboratories
CHD3 Polyclonal Antibody
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Product Details
IHC-00247
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1950 and 2000 of human chromodomain helicase DNA binding protein 3.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee and Chinese hamster
Target Information
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent chromatin remodeler CHD3; ATP-dependent helicase CHD3; CHD-3; Chromo domain-containing protein 3; chromodomain-helicase-DNA-binding protein 3; hZFH; MGC40857; Mi 2a; Mi-2 alpha; Mi-2 autoantigen 240 kDa protein; Mi2 ALPHA; Mi2-alpha; Prp9 1; unnamed protein product; zinc finger helicase; Zinc finger helicase-like; zinc-finger helicase (Snf2-like)
Gene Aliases: 2600010P09Rik; AF020312; CHD3; Chd7; Mi-2a; Mi2-ALPHA; Prp7; Prp9-1; SNIBCPS; ZFH
UniProt ID: (Human) Q12873
Entrez Gene ID: (Human) 1107, (Mouse) 216848
nucleotide binding
transcription regulatory region sequence-specific DNA binding
DNA binding
chromatin binding
RNA binding
helicase activity
protein binding
ATP binding
zinc ion binding
hydrolase activity
ATPase activity
histone binding
metal ion binding
ATP-dependent chromatin remodeler activity
poly(A) RNA binding
chromatin assembly or disassembly
spindle organization
centrosome organization
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
centrosome cycle
regulation of cell fate specification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of stem cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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