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Product Details
PA5-96099
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:200-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human CHD3. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
2.77 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2807901 |
Product Specific Information
Immunogen sequence: ERSILSRLAS KGTEPHPTPA YPPGPYATPP GYGAAFSAAP VGALAAAGAN YSQMPAGSFI TAATNGPPVL VKKEKEMVGA LVSDGLDRKE PRAGEVICID D; Positive Samples: Jurkat, Mouse brain, Rat brain ; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Target Information
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase CHD3; CHD-3; Chromodomain-helicase-DNA-binding protein 3; hZFH; MGC40857; Mi 2a; Mi-2 alpha; Mi-2 autoantigen 240 kDa protein; Mi2 ALPHA; Mi2-alpha; Prp9 1; Zinc finger helicase; zinc-finger helicase (Snf2-like)
Gene Aliases: 2600010P09Rik; AF020312; CHD3; Chd7; Mi-2a; Mi2-ALPHA; Prp7; Prp9-1; ZFH
UniProt ID: (Human) Q12873
Entrez Gene ID: (Human) 1107, (Mouse) 216848, (Rat) 303241
chromatin assembly or disassembly
spindle organization
centrosome organization
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
histone deacetylation
DNA duplex unwinding
regulation of signal transduction by p53 class mediator
biological_process
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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