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Invitrogen
CHD3 Recombinant Rabbit Monoclonal Antibody (R3C6)
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FIGURE: 1 / 3
CHD3 Antibody (MA572232) in ICC/IF
Immunocytochemistry analysis of CHD3 in HeLa cells. Permeabilized with Trinton X-100 at room temp for 20 min. Samples were incubated with CHD3 Recombinant Monoclonal (Product # MA572232 using a dilution at 1:100, for 90 min at 37°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green) at 37°C for 90 min, DAPI was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
Product Details
MA572232
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R3C6
Immunogen
KLH conjugated synthetic peptide derived from human CHD3.
Conjugate
Form
Liquid
Concentration
1.25 mg/mL
Amount
125 µg
Purification
Protein A
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent chromatin remodeler CHD3; ATP-dependent helicase CHD3; CHD-3; Chromo domain-containing protein 3; hZFH; MGC40857; Mi 2a; Mi-2 autoantigen 240 kDa protein; Mi2 ALPHA; Mi2-alpha; Prp9 1; unnamed protein product; zinc finger helicase; Zinc finger helicase-like; zinc-finger helicase (Snf2-like)
Gene Aliases: CHD3; Mi-2a; Mi2-ALPHA; SNIBCPS; ZFH
UniProt ID: (Human) Q12873
Entrez Gene ID: (Human) 1107
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
spindle organization
centrosome cycle
regulation of cell fate specification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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