PA5-32181 targets CHD4 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-32181 immunogen is recombinant fragment corresponding to a region within amino acids 462 and 1912 of Human CHD4.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
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Protein Aliases: ATP-dependent helicase CHD4; CHD-4; Chromodomain-helicase-DNA-binding protein 4; Mi-2 autoantigen 218 kDa protein; Mi-2 beta; Mi-2b; Mi2-BETA; MI2B
Gene Aliases: 9530019N15Rik; AA617397; BC005710; CHD-4; CHD4; D6Ertd380e; Mi-2b; Mi-2beta; Mi2-BETA; mKIAA4075