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Product Details
A301-081A
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000-1:10,000 | - |
Immunoprecipitation (IP) |
2-10 µg/mg lysate | - |
ChIP-sequencing (ChIP-Seq) |
10 µg/IP | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Between 25 and 75 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
tris citrate/phosphate, pH 7-8 |
Contains |
0.09% sodium azide |
Storage conditions |
4° C |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase CHD4; CHD-4; Chromodomain-helicase-DNA-binding protein 4; Mi-2 autoantigen 218 kDa protein; Mi-2 beta; Mi2-beta; MI2B
Gene Aliases: 9530019N15Rik; AA617397; BC005710; CHD-4; CHD4; D6Ertd380e; Mi-2b; Mi-2beta; Mi2-BETA; mKIAA4075
UniProt ID: (Human) Q14839, (Mouse) Q6PDQ2
Entrez Gene ID: (Human) 1108, (Mouse) 107932
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
histone deacetylation
DNA duplex unwinding
ATP-dependent chromatin remodeling
spindle assembly
terminal button organization
regulation of signal transduction by p53 class mediator
chromatin organization
regulation of transcription, DNA-templated
chromatin modification
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
DNA binding
ATP-dependent DNA helicase activity
histone deacetylase activity
protein binding
ATP binding
microtubule binding
zinc ion binding
nucleosomal DNA binding
nucleotide binding
nucleic acid binding
helicase activity
ATP-dependent helicase activity
transcription factor binding
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
metal ion binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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