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Invitrogen
CHI3L1 Polyclonal Antibody
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FIGURE: 1 / 1
CHI3L1 Antibody (PA5-79042) in WB
Western blot analysis of CHI3L1 in Lane 1: mouse RAW264.7 whole cell lysate, Lane 2: mouse HEPA1-6 whole cell lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with CHI3L1 polyclonal antibody (Product # PA5-79042) at a dilution of 0.5 µg/mL (overnight at 4°C),... View More
Product Details
PA5-79042
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived mouse CHI3L1 recombinant protein (Position: Y30-K262).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse RAW2647 whole cell, mouse HEPA1-6 whole cell.
Target Information
Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Breast regression protein 39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; hCGP39
Gene Aliases: AW208766; Brp39; Chi3l1; Chil1; Gp39
UniProt ID: (Mouse) Q61362
Entrez Gene ID: (Mouse) 12654
carbohydrate metabolic process
chitin catabolic process
apoptotic process
inflammatory response
activation of NF-kappaB-inducing kinase activity
positive regulation of peptidyl-threonine phosphorylation
lung development
positive regulation of angiogenesis
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
interleukin-8 secretion
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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