Immunogen sequence: MVSTPENRQ TFITSVIKFL RQYEFDGLDF DWEYPGSRGS PPQDKHLFTV LVQEMREAFE QEAKQINKPR LMVTAAVAAG ISNIQSGYEI PQLSQYLDYI HVMTYDLHGS WEGYTGENSP LYKYPTDTGS NAYLNVDYVM NYWKDNGAPA EKLIVGFPTY GHNFILSNPS NTGIGAPTSG AGPAGPYAKE SGIWAYYEIC TFLKNGATQG WDAPQEVPYA YQGNVWVGYD NIKSFDIKAQ WLKHNKFGGA MVWAIDLDDF TGTFCNQGKF PLISTLKKAL GLQSASCTAP AQPIEPITAA PSGSGNGSGS SSSGGSSGGS GFCAVRANGL YPVANNRNAF WHCVNGVTYQ QNCQAGLVFD TSCDCCNWA (109-476 aa encoded by BC036339)
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: acidic chitinase; Acidic mammalian chitinase; AMCase; eosinophil chemotactic cytokine; Lung-specific protein TSA1902; small acid mammalian chitinase; YNL
Gene Aliases: 2200003E03Rik; AMCASE; CHIA; Chia1; CHIT2; TSA1902; YNL