Immunogen sequence: EEEEAPPPPRV VSEEHLRRYA PDPVLVRGAG HITVFGL
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 95%.
This gene encodes a cysteine-rich hydrophobic (CHIC) domain-containing protein, and is one of the few protein-coding genes found near the X-inactivation center. Studies in mouse indicate that the mouse ortholog of this gene is subject to X-inactivation in mouse. Experiments with other CHIC domain-containing family members show that the cysteine residues are palmitoylated post-translationally, resulting in membrane association. Alternative splicing results in multiple transcript variants encoding different isoforms.
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