Keep as concentrated solution.
Predicted reactivity: Mouse (88%), Rat (88%), Pig (90%), Bovine (88%).
Positive Control: Jurkat, HeLa.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDS1 antibody; Cds1 homolog; cds1 homolog antibody; Checkpoint kinase 2; checkpoint-like protein CHK2; checkpoint-like protein CHK2 antibody; CHEK2 antibody; CHK2 antibody; CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe) antibody; CHK2 checkpoint homolog antibody; Hucds1; HuCds1 antibody; LFS2 antibody; PP1425 antibody; protein kinase CHK2 antibody; RAD53 antibody; Serine/threonine-protein kinase Chk2; serine/threonine-protein kinase Chk2 antibody
Gene Aliases: CDS1; CHEK2; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53
UniProt ID: (Human) O96017
Entrez Gene ID: (Human) 11200
Molecular Function: non-receptor serine/threonine protein kinase