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Proteintech
CHMP1A Polyclonal Antibody
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Product Details
15761-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHMP1A Fusion Protein Ag8389 (1-196 aa encoded by BC007527)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDDTLFQLK FTAKQLEKLA KKAEKDSKAE QAKVKKALLQ KNVECARVYA ENAIRKKNEG VNWLRMASRV DAVASKVQTA VTMKGVTKNM AQVTKALDKA LSTMDLQKVS SVMDRFEQQV QNLDVHTSVM EDSMSSATTL TTPQEQVDSL IMQIAEENGL EVLDQLSQLP EGASAVGESS VRSQEDQLSR RLAALRN (1-196 aa encoded by BC007527)
Target Information
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I, -II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: charged multivesicular body protein 1/chromatin modifying protein 1; Charged multivesicular body protein 1a; CHMP1; CHMP1a; chromatin modifying protein 1A; Chromatin-modifying protein 1a; hVps46-1; KIAA0047; procollagen (type III) N-endopeptidase; protease, metallo, 1, 33kD; unnamed protein product; Vacuolar protein sorting-associated protein 46-1; VPS46 homolog A; Vps46-1
Gene Aliases: 2900018H07Rik; CHMP1; CHMP1A; KIAA0047; PCH8; PCOLN3; PRSM1; VPS46-1; VPS46A
UniProt ID: (Human) Q9HD42, (Mouse) Q921W0
Entrez Gene ID: (Human) 5119, (Mouse) 234852
plasma membrane repair
autophagy
nucleus organization
vacuolar transport
mitotic chromosome condensation
mitotic metaphase plate congression
negative regulation of gene expression
regulation of centrosome duplication
protein transport
vesicle-mediated transport
nuclear envelope reassembly
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
late endosome to vacuole transport
viral budding from plasma membrane
cell division
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
ESCRT III complex disassembly
cell separation after cytokinesis
transcription, DNA-templated
regulation of transcription, DNA-templated
transport
cell cycle
gene silencing
negative regulation of transcription by glucose
negative regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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