CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 ).
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Protein Aliases: Charged multivesicular body protein 1b; Charged multivesicular body protein 1b-1; CHMP1.5; CHMP1b; CHMP1b-1; chromatin modifying protein 1B; Chromatin-modifying protein 1b; Chromatin-modifying protein 1b-1; vacuolar protein sorting 46-2; Vacuolar protein sorting-associated protein 46-2; Vps46-2
Gene Aliases: 2810405I11Rik; C10orf2; C18-ORF2; C18orf2; CHMP1.5; CHMP1B; Chmp1b1; hVps46-2; Vps46-2; Vps46B
Molecular Function: membrane traffic protein