This target displays homology in the following species: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A is required for both MVB formation and regulation of cell cycle progression.
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Protein Aliases: Charged multivesicular body protein 2a; CHMP2a; chromatin modifying protein 2A; Chromatin-modifying protein 2a; mVps2; putative breast adenocarcinoma marker; putative breast adenocarcinoma marker (32kD); Putative breast adenocarcinoma marker BC-2; Vacuolar protein sorting-associated protein 2; Vacuolar protein sorting-associated protein 2-1; vacuolar protein-sorting-associated protein 2; VPS2 homolog A; Vps2-1
Gene Aliases: 1500016L11Rik; BC-2; BC2; BOS_18186; CHMP2; CHMP2A; fj10d05; RGD1305050; VPS2; VPS2A; wu:fi18h03; wu:fj10d05; zgc:55361