The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006
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Protein Aliases: BC-2; BC2; Charged multivesicular body protein 2a; CHMP2; CHMP2a; chromatin modifying protein 2A; Chromatin-modifying protein 2a; putative breast adenocarcinoma marker (32kD); Putative breast adenocarcinoma marker BC-2; Vacuolar protein sorting-associated protein 2-1; VPS2; VPS2 homolog A; Vps2-1; VPS2A
Gene Aliases: BC-2; BC2; CHMP2; CHMP2A; VPS2; VPS2A
UniProt ID: (Human) O43633
Entrez Gene ID: (Human) 27243