PA5-29007 targets CHMP2B in IF and WB applications and shows reactivity with Human samples.
The PA5-29007 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 213 of Human CHMP2B.
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This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
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Protein Aliases: Charged multivesicular body protein 2b; CHMP2.5; CHMP2b; chromatin modifying protein 2B; Chromatin-modifying protein 2b; DMT1; Vacuolar protein sorting-associated protein 2-2; vacuolar protein-sorting-associated protein 2-2; VPS2 homolog B; VPS2-2; VPS2B
Gene Aliases: ALS17; CGI-84; CHMP2.5; CHMP2B; DMT1; VPS2-2; VPS2B
UniProt ID: (Human) Q9UQN3
Entrez Gene ID: (Human) 25978