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Proteintech
CHMP4B Polyclonal Antibody
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Product Details
13683-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHMP4B Fusion Protein Ag4544 (1-224 aa encoded by BC033859)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is highly specific to the CHMP4B and it doesn't cross-react with other CHMPs as well as other CHMP4s (CHMP4A and CHMP4C).
Immunogen sequence: MSVFGKLFG AGGGKAGKGG PTPQEAIQRL RDTEEMLSKK QEFLEKKIEQ ELTAAKKHGT KNKRAALQAL KRKKRYEKQL AQIDGTLSTI EFQREALENA NTNTEVLKNM GYAAKAMKAA HDNMDIDKVD ELMQDIADQQ ELAEEISTAI SKPVGFGEEF DEDELMAELE ELEQEELDKN LLEISGPETV PLPNVPSIAL PSKPAKKKEE EDDDMKELEN WAGSM (1-224 aa encoded by BC033859)
Target Information
CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Charged multivesicular body protein 4b; CHMP4b; chromatin modifying protein 4B; Chromatin-modifying protein 4b; hSnf7-2; similar to yeast Snf7p; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; SNF7-2; Vacuolar protein sorting-associated protein 32-2; vacuolar protein-sorting-associated protein 32-2; Vps32-2
Gene Aliases: 2010012F05Rik; C20orf178; C76846; CHMP4A; CHMP4B; CTPP3; CTRCT31; dJ553F4.4; RGD1309846; RGD1565889; SHAX1; SNF7; SNF7-2; Vps32-2; VPS32B
UniProt ID: (Human) Q9H444, (Mouse) Q9D8B3
Entrez Gene ID: (Human) 128866, (Mouse) 75608, (Rat) 100359642
mitotic cytokinesis
plasma membrane repair
posttranslational protein targeting to membrane
membrane budding
autophagy
nucleus organization
vacuolar transport
mitotic metaphase plate congression
exit from mitosis
regulation of centrosome duplication
protein transport
macroautophagy
nuclear envelope reassembly
late endosome to vacuole transport via multivesicular body sorting pathway
multivesicular body assembly
maintenance of lens transparency
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding
viral budding from plasma membrane
neurological system process
protein polymerization
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
cell separation after cytokinesis
transport
regulation of viral process
protein homooligomerization
negative regulation of cell death
negative regulation of neuron death
positive regulation of viral release from host cell
negative regulation of autophagosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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